Travel packages in Italy

Road trips in Italy

7-Day Italy Self-Drive Road Trip With Itinerary from Perugia traveling south to Rome and Siena

1 / 59

Porta di Venere, from the Roman era, made of white travertine, with its three arches and the two towers of Properzio in Perugia, Italy

Photo of Christmas in Assisi, Saint Francis Basilica with the Christmas Crib. Province of Perugia, Umbria, Italy.

7-Day Italy Self-Drive Road Trip With Itinerary from Perugia traveling south to Rome and Siena

Perfect travel plans

Everything included

Fully customizable

Description

Included

Flights

Select dates

Hotel

Select dates

Car rental

Select dates

Tours & tickets

Select dates

Travel plan

From A to Z

Travel agent

24/7 fast service

Description

Experience the freedom of the open road on an unforgettable 7-day road trip in Italy! Embark on a self-drive tour that caters to every traveler, featuring destinations like Perugia, Rome, Siena, and Santa Maria degli Angeli.

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 2 nights in Perugia, 3 nights in Rome, and 1 night in Siena. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Perugia, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Perugia, Rome, Siena, and Santa Maria degli Angeli, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

Travel details

Set your travel details to find the best price

Flights

Compare and choose from the best flights to Perugia

Include flights

Car

Choose from the best car rental deals or see all options

Driver’s age is 30 - 65

I live in

Pick-up: 10:00

Drop-off: 10:00

Include car

Personalize your itinerary

Customize tours under each day and destination

Day1

Day 1

Perugia - Arrival day
More

Piazza IV Novembre
More

Your road trip adventure in Italy begins as soon as you reach Perugia and pick up your car. You’ll stay here for 1 night and explore what to see in Perugia, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Perugia is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza Iv Novembre. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Perugia. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Perugia, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Ristorante Settimo Sigillo, a highly-rated dining destination in Perugia. If you're eager to try something different, consider Caffè Baglioni, another top spot with a tantalizing menu. You might also want to secure a reservation at Bar Pellas. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Perugia this evening.

Unwind after your meal by stepping into Tommi Bar. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Valentina offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Caffe Dal Perugino, another top-rated bar in the area.

Raise a toast to the start of your 7-day road trip in Italy!

Day2

Day 2

Perugia
Rome
More

Drive 184 km, 2 hours 33 min

Carducci Gardens
Porta Marzia
Rocca Paolina
More

Dive into day 2 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Perugia. At the end of the day, you’ll unwind at one of the finest accommodations in Rome, where you'll spend 3 nights.

Let Carducci Gardens set the tone for the day. Spend some time admiring this enchanting park before continuing your journey. Porta Marzia is your next stop. This worthwhile monument is one of the best-rated sights in Perugia.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Rocca Paolina. This instagrammable historical landmark is a sight to behold.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for a true cultural experience.

Experience a symphony of flavors at La Pergola in Rome by securing a reservation in advance. Renowned for its 3-star Michelin distinction, La Pergola delights its guests with its exceptional variety of meals showcasing delicious mediterranean and contemporary cuisine. For a palate-pleasing alternative, make sure to dine at Il Pagliaccio, acclaimed for its delectable creative and innovative specialties. This local 2-star Michelin establishment consistently satisfies guests, ensuring an unforgettable holiday experience. Want to go on another culinary journey? Delight your senses at Enoteca La Torre, a top-rated restaurant known for its outstanding menu. Known as a top-rated 2-star Michelin establishment, it's a top choice for mediterranean and creative cuisine in the city.

If you’re not ready to end the night just yet, La Botticella Of Poggi Giovanni offers a perfect venue to relax and savor a drink. Similarly, Almalu Trastevere is well-suited for those looking to unwind in a social setting. Bar Viminale Di Pepi Maurilio is another excellent spot to enjoy a nightcap after a delightful meal.

Relax and recharge in preparation for another adventurous day in Italy!

Day3

Day 3

Rome
More

Drive 5 km, 1 hour 9 min

Colosseum
Roman Forum
Altare della Patria
Pantheon
Piazza Navona
More

Day 3 offers an itinerary packed with the best things to see in Perugia. You’ll stay in Rome for 2 nights more, offering you enough time to explore at a relaxed pace.

Colosseum makes a great addition to your morning plans. This iconic archeological site is an UNESCO world heritage-listed place to see in Rome. Continue your discovery at Roman Forum, a culturally significant archeological site with stories to tell.

As you stroll around Rome, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Altare Della Patria. This captivating monument offers a detailed encounter with Rome. Next, make your way to Pantheon to add another highlight to your day. After that, visit Piazza Navona, a timeless public square that’s sure to impress. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Rome.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at RomAntica, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Coso Ristorante, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of DEROMA - Farine Romane, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Round off your dining experience by visiting Sant' Eustachio Caffè, a prime location for a drink. Alternatively, explore the distinctive characteristics of Yellowsquare Rome, a bar catering to every mood and preference. Caffè Portofino likewise offers a unique atmosphere, perfect for a memorable night out.

Relax and look forward to more memorable moments to come!

Day4

Day 4

Rome
More

Drive 8 km, 1 hour 2 min

Trevi Fountain
Piazza di Spagna
Spanish Steps
piazza del Popolo
Villa Borghese
More

On day 4 of your road trip, you will have an entire day to discover what to see in Rome. You’ll stay in Rome for 1 night.

Whatever your travel style is, Trevi Fountain is an essential stop in Rome. This wondrous monument provides an insightful glimpse into the city's identity. Next, discover Piazza Di Spagna, a visually striking public square, promising a delightful encounter.

Continue your sightseeing with a visit to Spanish Steps, an impressive public square. When you’re done, don’t forget to make a stop at the impressive Piazza Del Popolo. Round off your day at Villa Borghese, another gem in Rome with serene features to discover.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Treat yourself to a delicious dinner at Hotel de Russie, an excellent option for tonight's dining. Looking for something different? La Taverna Italiana offers a tantalizing alternative with its diverse menu. And don’t miss The Parrot Bar. Known for great service, it’s a fantastic choice for tonight in Rome.

Keep the evening going at The Apartment Bar Roma, a great choice for enjoying the after-dinner hours with a drink. You could also go to Hotel Hassler Roma, which offers a similarly pleasant setting and great drinks.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Day5

Day 5

Rome
Vatican City
Siena
More

Drive 242 km, 2 hours 57 min

St Peter's Basilica
More

Experience an unparalleled adventure on day 5 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Vatican City. At the end of the day, you will retreat to the hotel of your choice in Siena, where will spend 1 night.

As you explore Vatican City’s charming streets, take in the lively atmosphere and get to know the character of the city.

Vatican City’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Rome behind. This drive usually takes around 9 min. Vatican City welcomes you with a multitude of unique vacation experiences.

For a more meaningful self-guided tour of the city's best attractions, visit St. Peter's Basilica, a timeless major basilica that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey.

When you’re done exploring for the day, you’ll drive to your hotel in Siena. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Siena, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Enoteca I Terzi, a highly-rated dining destination in Siena. If you're eager to try something different, consider Ristorante Tar-Tufo, another top spot with a tantalizing menu. You might also want to secure a reservation at Antica Trattoria Papei. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Siena this evening.

Continue the enjoyment post-dinner at Meet Life Cafè, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Maudit Pub offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Bar Impero Siena. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Head back to your accommodation in Siena and get some rest to prepare for another magical day of your road trip in Italy.

Day6

Day 6

Siena
Assisi
Perugia
More

Drive 146 km, 2 hours 15 min

Siena Cathedral
piazza del Campo
Pubblico Palace
Basilica of San Francesco d'Assisi
More

Your itinerary for day 6 of your road trip in Italy includes 2 stops and features some of the highlights of Siena and Santa Maria degli Angeli. At the end of the day, enjoy the comforts of a top-rated hotel in Perugia, where you'll spend 1 night.

Siena Cathedral leaves a lasting impression. This church is one of the most locally renowned places to visit in Siena. Next, head to Piazza Del Campo, an extraordinary public square, known for its visually striking features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Pubblico Palace. This culturally significant palace is a highly recommended experience.

Set your GPS to Santa Maria degli Angeli and hit the road. Expect a journey of approximately 1 hour 34 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Santa Maria degli Angeli beckons with new experiences!

Our first attraction recommendation in Santa Maria degli Angeli is Basilica Of San Francesco D'assisi, an interesting church that draws attention for its UNESCO world heritage-designated features.

At the end of the day, you will drive to Perugia, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Perugia. Enjoy a relaxing evening as you savor delicious local cuisine.

Dine in style at La Taverna, a top recommendation for dinner tonight. Or, for a change of pace, Ristorante del Sole boasts a menu that's sure to impress. Also, be sure to check out Al Mangiar Bene. Known as a local hotspot, it’s a great choice for tonight in Perugia.

Round off your dining experience by visiting Caffè Fortebraccio, a prime location for a drink. Alternatively, explore the distinctive characteristics of Caffe Del Banco, a bar catering to every mood and preference. Dempsey's Perugia likewise offers a unique atmosphere, perfect for a memorable night out.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

Day7

Day 7

Perugia - Departure day
More

Etruscan Arch
More

Day 7 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Perugia before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Etruscan Arch. This increasingly popular historical landmark is a hotspot among locals.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Perugia.

Savor the flavors at Perugia Plaza Hotel, a top pick for dinner tonight. Alternatively, Elfo Pub Perugia beckons with its unique menu offerings.

You’ll then say farewell to Perugia. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

How it works

Book your journey with Europe’s biggest travel platform—expert itineraries, instant confirmation, and full flexibility with 24/7 support.

Secure your spot

Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.

Get instant confirmation

Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.

Personalize your itinerary

Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.

Easily make changes

Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.

Enjoy seamless planning

With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.

Explore with confidence

From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

Secure your spot

Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.

Get instant confirmation

Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.

Personalize your itinerary

Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.

Easily make changes

Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.

Enjoy seamless planning

With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.

Explore with confidence

From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

We guarantee

Your trip is protected, personalized, and priced right. No surprises, no stress.

Similar travel packages

Discover other popular vacations in Italy

From 0

Install Europe’s biggest travel app

Download Europe’s biggest travel marketplace to your phone to manage your entire trip in one place

Scan this QR code with your phone camera and press the link that appears to add Europe’s biggest travel marketplace into your pocket. Enter your phone number or email address to receive an SMS or email with the download link.