7-Day Italy Self-Drive Road Trip With Itinerary from Perugia to Florence

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Porta di Venere, from the Roman era, made of white travertine, with its three arches and the two towers of Properzio in Perugia, Italy
Photo of Christmas in Assisi, Saint Francis Basilica with the Christmas Crib. Province of Perugia, Umbria, Italy.
7-Day Italy Self-Drive Road Trip With Itinerary from Perugia to Florence
7-Day Italy Self-Drive Road Trip With Itinerary from Perugia to Florence
7-Day Italy Self-Drive Road Trip With Itinerary from Perugia to Florence
7-Day Italy Self-Drive Road Trip With Itinerary from Perugia to Florence
7-Day Italy Self-Drive Road Trip With Itinerary from Perugia to Florence
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Explore the best of Italy on a remarkable 7-day road trip! Combine exploration with relaxation on a self-drive tour featuring Perugia, Santa Maria degli Angeli, Florence, Pisa, Lucca, Siena, San Gimignano, Orvieto, and Todi.

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 3 nights in Perugia and 3 nights in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Perugia, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Perugia, Santa Maria degli Angeli, Florence, Pisa, Lucca, Siena, San Gimignano, Orvieto, and Todi, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
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Day1

Day 1

  • Perugia - Arrival day
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  • Rocca Paolina
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Welcome to Perugia, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 2 nights discovering what to see in Perugia before embarking on the next leg of your journey.

Perugia is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Rocca Paolina. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Perugia. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Perugia, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Ristorante Settimo Sigillo, an iconic dining spot in Perugia. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Caffè Baglioni, a popular restaurant in Perugia. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Bar Pellas, a hidden gem nestled in Perugia. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Round off your dining experience by visiting Tommi Bar, a prime location for a drink. Alternatively, explore the distinctive characteristics of Valentina, a bar catering to every mood and preference. Caffe Dal Perugino likewise offers a unique atmosphere, perfect for a memorable night out.

Raise a toast to the start of your 7-day road trip in Italy!

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Day2

Day 2

  • Perugia
  • Assisi
  • More

Drive 62 km, 1 hour 59 min

  • National Archaeological Museum of Umbria
  • Frontone Gardens
  • Basilica of San Francesco d'Assisi
  • Piazza del Comune
  • Basilica di Santa Chiara
  • Eremo delle Carceri
  • More

On day 2 of your road trip, you’ll start and end your day in Perugia, where you still have 1 night left. You'll spend part of the day exploring places of interest outside the immediate city, including Perugia and Santa Maria degli Angeli.

Catch National Archaeological Museum Of Umbria before the crowds roll in. This instagrammable museum is sure to ignite your curiosity. Next, dive into the eye-catching features of Frontone Gardens, a must-visit park in the city.

Fasten your seatbelt and make your way to your next stop — Santa Maria degli Angeli, home to many well-known sights in the region. Keep in mind that your travel time from Perugia to Santa Maria degli Angeli may take around 25 min without traffic disruptions. Upon arrival in Santa Maria degli Angeli, we highly recommend checking out some of the top attractions.

Spend your afternoon discovering Basilica Of San Francesco D'assisi, a popular church known for its picture-perfect features. Next, continue your sightseeing at Piazza Del Comune, an up-and-coming public square.

If you're starting to feel hungry, this is a great time for a break at a nearby restaurant or cafe. When you're ready for more, stop by Basilica Di Santa Chiara and uncover the details of this breathtaking church. Make sure to also explore Eremo Delle Carceri, an intriguing monastery.

When you’re done exploring for the day, you’ll return to Perugia and your accommodation.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Perugia, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at La Taverna, a highly-rated dining destination in Perugia. If you're eager to try something different, consider Ristorante del Sole, another top spot with a tantalizing menu. You might also want to secure a reservation at Al Mangiar Bene. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Perugia this evening.

Continue the enjoyment post-dinner at Caffè Fortebraccio, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Caffe Del Banco offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Dempsey's Perugia. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day3

Day 3

  • Perugia
  • Florence
  • More

Drive 152 km, 2 hours 38 min

  • piazzale Michelangelo
  • Basilica of Santa Croce in Florence
  • Uffizi Gallery
  • Ponte Vecchio
  • Cathedral of Santa Maria del Fiore
  • piazza della Signoria
  • More

Your itinerary for day 3 of your road trip in Italy includes 1 stop and features some of the highlights of Florence. At the end of the day, enjoy the comforts of a top-rated hotel in Florence, where you'll spend 3 nights.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Florence. This drive usually takes around 1 hour 49 min, without any stops or traffic disruptions.

Set out on a self-guided sightseeing tour at Piazzale Michelangelo and explore the romantic features. Next, make your way to Basilica Of Santa Croce In Florence, another highlight in Florence. When you’re done exploring the church, continue to Uffizi Gallery, a picture-perfect art gallery.

Nearby, you will also find Ponte Vecchio. This iconic historical landmark is a top place to see in the area. Lastly, head to Cathedral Of Santa Maria Del Fiore, a romantic church that is perfect for some final exploring in the city.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for a true cultural experience.

Enjoy a delicious meal at Ristorante Oliviero 1962, a top-rated dining destination in Florence. If you're in the mood to try something new, consider Di Poneta Novoli, another top spot with a mouthwatering menu. You might also want to secure a reservation at Caffe San Firenze. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Florence this evening.

If you’re not ready to end the night just yet, Manifattura offers a perfect venue to relax and savor a drink. Similarly, Se·sto On Arno Rooftop Bar is well-suited for those looking to unwind in a social setting. Il Vinile is another excellent spot to enjoy a nightcap after a delightful meal.

Celebrate another amazing day of your road trip adventure in Italy!

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Day4

Day 4

  • Florence
  • Pisa
  • Lucca
  • More

Drive 196 km, 3 hours 17 min

  • Piazza del Duomo, Pisa
  • Leaning Tower of Pisa
  • Piazza dell'Anfiteatro
  • Guinigi Tower
  • Walls of Lucca
  • More

Greet day 4 of your road trip in Italy with a smile and start your day with a hearty breakfast. You have 2 nights to stay in Florence, so get ready to make the most of your time in the region. On the agenda for this day, you’ll find only the best things to see and do in Pisa and Lucca.

Continue your road trip and head to your next destination, Pisa. This car ride takes around 1 hour 16 min.

When you're ready for some sights, head to Piazza Del Duomo, Pisa, a world-famous public square in Pisa. Explore its breathtaking features at your own pace before you continue your journey to your next attraction, Leaning Tower Of Pisa. This world-famous monument is a top recommendation in the area.

Set your GPS to Lucca and hit the road. Expect a journey of approximately 32 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Lucca beckons with new experiences!

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Piazza Dell'anfiteatro, an interesting public square that everyone visiting Lucca should see. Next, head to Guinigi Tower. This enchanting monument is one of the most intriguing attractions in the region.

If you're keen to see more, don’t miss out on Mura Di Lucca, a majestic historical landmark popular among locals as well as travelers.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Florence.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a lovely meal at Ditta Artigianale, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Trattoria Da Burde is another top choice with a popular menu. You could also check for a table at Casa Toscana. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Florence tonight.

Keep the excitement of the evening going by visiting a bar or two. Bar 50 Rosso is an excellent place to start. You could also check out Bitter Bar, offering a different kind of charm. A last recommendation for the day is Archea Brewery. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day5

Day 5

  • Florence
  • Siena
  • San Gimignano
  • More

Drive 181 km, 3 hours 47 min

  • Pubblico Palace
  • piazza del Campo
  • Siena Cathedral
  • Fortezza Medicea
  • Porta Camollia, Siena
  • Piazza del Duomo, San Gimignano
  • More

On day 5 of your road trip in Italy, you’ll start and end your day in Florence, but spend the day exploring what’s beyond the city. Since you still have 1 night to spend in Florence, there’s no need to rush. Experience Siena and San Gimignano to the fullest today with this curated day itinerary.

Siena’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Florence behind. This drive usually takes around 1 hour 15 min. Siena welcomes you with a multitude of unique vacation experiences.

One of our top recommendations for your sightseeing is Pubblico Palace. Spend some time admiring the picture-perfect features of the palace before you continue to your next stop. Then, head to Piazza Del Campo. This famous public square is a traveler-favorite in the city.

If you're keen to see more, continue to Siena Cathedral. Feed your curiosity by learning something new about the church. Next, take your journey to Fortezza Medicea (siena), a frequently visited monument. Conclude your sightseeing at Porta Camollia, Siena, known for its culturally significant features.

After soaking in Siena’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: San Gimignano. Expect your car journey to take a minimum of 48 min. When you arrive in San Gimignano, it's time to take a break from the road.

When you're ready for some sights, head to Piazza Del Duomo, a curiosity-inducing public square in San Gimignano. Explore its romantic features at your own pace before you continue your journey.

When you’re done exploring for the day, you’ll return to Florence and your accommodation.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Make sure to reserve a table at Ristorante Buca Mario, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Agricola Toscana, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Eataly Firenze, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

If you’re not ready to end the night just yet, Gosh* offers a perfect venue to relax and savor a drink. Similarly, Antico Caffè Del Moro - Art Bar Firenze is well-suited for those looking to unwind in a social setting. Quelo Bar is another excellent spot to enjoy a nightcap after a delightful meal.

Savor another day of unforgettable experiences in Italy!

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Day6

Day 6

  • Florence
  • Orvieto
  • Todi
  • Perugia
  • More

Drive 247 km, 3 hours 53 min

  • Well of St Patrick
  • Orvieto Cathedral
  • Orvieto subterranea
  • Torre del Moro Orvieto
  • Pozzo della Cava
  • piazza del Popolo
  • More

On day 6 of your road trip in Italy, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Orvieto and Todi are on today's agenda. In the evening, you’ll end up in Perugia, where you will stay for 1 night.

Continue your road trip and head to your next destination, Orvieto. This car ride takes around 1 hour 54 min.

Spend your afternoon discovering Well Of St. Patrick, a popular monument known for its picture-perfect features.

After soaking in Florence’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Orvieto. Expect your car journey to take a minimum of 1 hour 54 min. When you arrive in Orvieto, it's time to take a break from the road.

When you're ready for some sights, head to Orvieto Cathedral, a locally renowned church in Orvieto. Explore its visually striking features at your own pace before you continue your journey to your next attraction, Orvieto Underground. This locally appreciated cave system is a top recommendation in the area.

When you’re ready to explore more, Torre Del Moro Orvieto is an excellent choice. Spend some time discovering what some claim to be the most historic monument in the region. Next, continue your sightseeing at the locally appreciated Pozzo Della Cava and discover what makes this cave unique.

Embrace the thrill of the open road as you wave goodbye to Orvieto and set your GPS to Todi. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 47 min. Upon reaching Todi, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Piazza Del Popolo, an intriguing public square that everyone visiting Todi should see.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Perugia. Perugia offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Perugia, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Perugia Plaza Hotel, an iconic dining spot in Perugia. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Elfo Pub Perugia, a popular restaurant in Perugia. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Sangallo Palace Hotel, a hidden gem nestled in Perugia. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

After enjoying a fulfilling meal, continue your evening at Il Birrino, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Quei Bravi Ragazzi offers a welcoming atmosphere for easing into the nightlife. Similarly, Lo Chalet - Lounge Bar provides an excellent environment for a relaxed and enjoyable evening.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day7

Day 7

  • Perugia - Departure day
  • More
  • The Fontana Maggiore
  • More

Day 7 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Perugia before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting The Fontana Maggiore, a culturally significant monument before you head out.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Perugia.

You’ll then say farewell to Perugia. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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