6-Day Italy Self-Drive Road Trip With Itinerary from Ancona traveling west to Perugia and Rome

Your itinerary for day 2 of your road trip in Italy includes 3 stops and features some of the highlights of Ancona, Serra San Quirico, and San Vittore. At the end of the day, enjoy the comforts of a top-rated hotel in Perugia, where you'll spend 1 night.

One of the most locally appreciated attractions included on the itinerary is Porta Pia. This breathtaking monument will help you start your sightseeing on top. Then, take a leisurely stroll to Lazzaretto Of Ancona and learn what makes this heritage-rich museum unique.

Throughout the day, make sure to take breaks to appreciate the surroundings.

When you’ve had your share of Ancona, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Serra San Quirico. Your travel time is around 48 min.

For a more meaningful self-guided tour of the city's best attractions, visit Parco Naturale Regionale Gola Della Rossa E Di Frasassi, a locally appreciated nature reserve that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey.

Fasten your seatbelt and make your way to your next stop — San Vittore, home to many well-known sights in the region. Keep in mind that your travel time from Serra San Quirico to San Vittore may take around 13 min without traffic disruptions. Upon arrival in San Vittore, we highly recommend checking out some of the top attractions.

Spend your afternoon discovering Frasassi Caves, a well-known cave system known for its picturesque features. Next, continue your sightseeing at San Vittore Alle Chiuse, a frequently visited church.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Perugia. Perugia offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Perugia. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delightful dinner at Ristorante Settimo Sigillo, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Caffè Baglioni? It's another excellent option with a diverse menu. Consider reserving a table at Bar Pellas as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Perugia.

Let the evening flow smoothly from dinner to drinks at Tommi Bar, a top-rated bar in the area. For other recommendations, Valentina provides a perfect setting for rounding out your night with style and great drinks. Likewise, Caffe Dal Perugino offers a memorable night with diverse drink options and excellent service.

Relax and look forward to more memorable moments to come!

Dive into day 3 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Vatican City. At the end of the day, you’ll unwind at one of the finest accommodations in Rome, where you'll spend 2 nights.

After soaking in Perugia’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Vatican City, Vatican City. Expect your car journey to take a minimum of 2 hours 17 min. When you arrive in Vatican City, it's time to take a break from the road.

Savor the day by heading to Vatican Museums, an iconic art museum that draws visitors from near and far.

Next, explore Sistine Chapel, yet another famous place to see in the area. After the chapel, make time to go to St. Peter's Basilica.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Enjoy an outstanding dining experience at La Pergola, a 3-star Michelin restaurant offering an exceptional mediterranean and contemporary menu. Alternatively, if you're in the mood for something different, consider the nearby 2-star Michelin-awardee, Il Pagliaccio, known for its delicious creative and innovative cuisine. Another highly-recommended place to eat in Rome is Enoteca La Torre, a renowned restaurant with a 2-star Guide Michelin recognition and a delicious mediterranean and creative menu.

After savoring a delicious meal, step into the vibrant nightlife at La Botticella Of Poggi Giovanni, where the evening is just getting started. In the same way, Almalu Trastevere offers a unique charm perfect for experiencing the local bar scene in Rome. Bar Viminale Di Pepi Maurilio is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Celebrate another amazing day of your road trip adventure in Italy!

Day 4 offers an itinerary packed with the best things to see in Ancona. You’ll stay in Rome for 1 night more, offering you enough time to explore at a relaxed pace.

Trastevere is a fantastic place you can explore today in Rome. This neighborhood is a testament to the city’s character, and it's easy to spend hours just walking around and admiring the surroundings. Soak in the Rome-way-of-life and visit all the nearby sights.

One of the most wondrous attractions included on the itinerary is Piazza Navona. This history-steeped public square will help you start your sightseeing on top. Then, take a leisurely stroll to Pantheon and learn what makes this heritage-rich monument unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the world-famous Trevi Fountain. After exploring the monument, head to Piazza Di Spagna. This iconic public square is a highlight in Rome.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for a true cultural experience.

Enjoy a delicious meal at RomAntica, a highly-rated dining destination in Rome. If you're eager to try something different, consider Coso Ristorante, another top spot with a tantalizing menu. You might also want to secure a reservation at DEROMA - Farine Romane. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Rome this evening.

Continue your evening by exploring the vibrant nightlife scene at Sant' Eustachio Caffè, a prime destination for a thrilling night out. Also, don’t forget to check out Yellowsquare Rome, a bar that offers unique local touches. Likewise, Caffè Portofino provides an excellent alternative for a fun evening.

Head back to your accommodation in Rome and get some rest to prepare for another magical day of your road trip in Italy.