12-Day Italy Self-Drive Road Trip With Itinerary from Trieste to Venice, Florence, Siena, Rome, and Santa Maria degli Angeli

On day 2 of your road trip, you'll get the chance to experience Miramare / Miramar and Trieste. At the end of the day, you'll drive back to Trieste, where you still have 1 night left to stay.

Canale Ponterosso Trieste is perfect for a self-paced visit during the day. This romantic street is sure to impress. Next on your list is Palazzo Gopcevich, another must-visit landmark and frequently visited palace renowned for its heritage-rich features.

While exploring and sightseeing, take time to savor the culture of Trieste by sampling some local delicacies. When you’re ready for more sightseeing, head to Molo Audace. This enchanting pier is an essential place to visit for anyone looking for the full Trieste experience. We also recommend visiting Piazza Unità D'italia, a notable public square. Nearby, you'll also find Cattedrale Di San Giusto Martire, ready to add charm to your journey.

After soaking in Trieste’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Miramare / Miramar. Expect your car journey to take a minimum of 18 min. When you arrive in Miramare / Miramar, it's time to take a break from the road.

Miramare Castle is an interesting castle we recommend visiting today. Discover its visually striking features before continuing your self-guided tour.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Trieste.

Trieste is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Trieste.

Treat yourself to a delicious dinner at Rustiko, an excellent option for tonight's dining. Looking for something different? Caffè San Marco offers a tantalizing alternative with its diverse menu. And don’t miss Osteria Marise. Known for great service, it’s a fantastic choice for tonight in Trieste.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Mast, known for its inviting atmosphere. Urbanis is another great option if you’re looking for a place to get the night started. Similarly, Coktail Bar Trieste | La Preferita provides a great setting to enjoy the night away.

Raise your glass to another unforgettable day in Italy!

Your itinerary for day 3 of your road trip in Italy includes 1 stop and features some of the highlights of Venice. At the end of the day, enjoy the comforts of a top-rated hotel in Venice, where you'll spend 2 nights.

Throughout the day, make sure to take breaks to appreciate the surroundings.

Set your GPS to Venice and hit the road. Expect a journey of approximately 2 hours 17 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Venice beckons with new experiences!

When you're ready for some sights, head to Bridge Of Sighs, a notable monument in Venice. Explore its history-steeped features at your own pace before you continue your journey to your next attraction, Doge's Palace. This interesting palace is a top recommendation in the area.

When you’re ready to explore more, St Mark's Basilica is an excellent choice. Spend some time discovering what some claim to be the most history-steeped church in the region. Next, continue your sightseeing at the globally renowned Piazza San Marco and discover what makes this public square unique. If you’re up for one more stop in the city, head to Palazzo Contarini Del Bovolo, a romantic palace many travelers find the visit worthwhile.

When you’re done exploring for the day, you’ll drive to your hotel in Venice. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Venice, it's often a good idea to reserve a table in advance.

Treat yourself to a delicious dinner at Bauer Hotel, an excellent option for tonight's dining. Looking for something different? L'Osteria Le Guglie offers a tantalizing alternative with its diverse menu. And don’t miss Corner Pub. Known for great service, it’s a fantastic choice for tonight in Venice.

Cap off your dinner by heading to Al Parlamento, ideal for a leisurely evening with a drink in hand. The Caffe Rosso is another bar that offers an enjoyable setting. Similarly, Adagio is also a popular place to go on a night out, perfect for relaxing and socializing.

Relax and recharge in preparation for another adventurous day in Italy!

On day 4 of your road trip, you’ll start and end your day in Venice, where you have 1 night left to stay.

Cannaregio is a fantastic place you can explore today in Murano. This neighborhood is a testament to the city’s character, and it's easy to spend hours just walking around and admiring the surroundings. Soak in the Murano-way-of-life and visit all the nearby sights.

Let Santa Maria Gloriosa Dei Frari set the tone for the day. Spend some time admiring this culturally significant church before continuing your journey. Gallerie Dell'accademia is your next stop. This often recommended art gallery is one of the best-rated sights in Venice.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Peggy Guggenheim Collection. This masterful art gallery is a sight to behold. To round off your sightseeing experience, visit Santa Maria Della Salute.

Fasten your seatbelt and make your way to your next stop — Murano, home to many well-known sights in the region. Upon arrival in Murano, we highly recommend checking out some of the top attractions.

Set out on a self-guided sightseeing tour at Murano Lighthouse and explore the visually striking features.

When you’re done exploring for the day, you’ll return to Venice and your accommodation.

After a day of adventure, treat yourself to an exquisite dinner at one of Venice's best restaurants.

Enjoy a delicious meal at Generator Venice, a highly-rated dining destination in Venice. If you're eager to try something different, consider Nevodi, another top spot with a tantalizing menu. You might also want to secure a reservation at Ristorante La Piazza. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Venice this evening.

Cap off your dinner by heading to Il Mercante, ideal for a leisurely evening with a drink in hand. The Irish Pub Venezia is another bar that offers an enjoyable setting. Similarly, Ai Stagneri is also a popular place to go on a night out, perfect for relaxing and socializing.

Say good night to Venice and look forward to another great day of your road trip in Italy!

On day 5 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Florence. When you’re not sightseeing, take time to relax at your chosen hotel in Florence, where you’ll be staying for 2 nights.

When you’re ready to jump back into the car and say goodbye to Venice, you’ll hit the road in the direction of Florence. This drive usually takes around 2 hours 52 min.

Savor the day by heading to Pitti Palace, a captivating palace that draws visitors from near and far. When you're done, continue to Ponte Vecchio, where you can soak in the enchanting surroundings.

Next, explore Uffizi Gallery, yet another top-rated place to see in the area. After the art gallery, make time to go to Fountain Of Neptune. This enchanting monument is well worth the visit. Lastly, head to Piazza Della Signoria, a spectacular public square you won’t want to miss.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Enjoy a lovely meal at Ristorante Oliviero 1962, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Di Poneta Novoli is another top choice with a popular menu. You could also check for a table at Caffe San Firenze. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Florence tonight.

Extend your evening after a delightful meal by visiting Manifattura, which offers the perfect atmosphere for a night out. Moreover, Se·sto On Arno Rooftop Bar is another popular option for a drink or two. Likewise, Il Vinile also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Take some time to reflect on your day and savor another beautiful night in Italy.

Day 6 of your road trip will take you to the best attractions Florence has to offer. Cherish the 1 night you have left in the city and use the provided itinerary to discover what to see in Florence.

To truly experience Florence, make sure to drop by Piazzale Michelangelo. This extraordinary observation deck is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Basilica Of Santa Croce In Florence, one of the city’s best highlights.

Next, check out Cathedral Of Santa Maria Del Fiore, one of the most spectacular places to see in Florence. This church is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Central Market. Wander around and soak in the instagrammable atmosphere this food market offers. Then, head to Galleria Dell'accademia, a top-rated art gallery that adds another dimension to your day. Finally, visit the locally renowned David, the last of our attraction recommendations for today.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Florence is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Florence.

Savor the flavors at Ditta Artigianale, a top pick for dinner tonight. Alternatively, Trattoria Da Burde beckons with its unique menu offerings. Also, consider Casa Toscana. With its consistent customer satisfaction, it’s an excellent option for dining in Florence tonight.

Keep the excitement of the evening going by visiting a bar or two. Bar 50 Rosso is an excellent place to start. You could also check out Bitter Bar, offering a different kind of charm. A last recommendation for the day is Archea Brewery. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Relax and recharge in preparation for another adventurous day in Italy!

Dive into day 7 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Siena. At the end of the day, you’ll unwind at one of the finest accommodations in Siena, where you'll spend 1 night.

Embrace the thrill of the open road as you wave goodbye to Florence and set your GPS to Siena. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 1 hour 10 min. Upon reaching Siena, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

For a more meaningful self-guided tour of the city's best attractions, visit Fortezza Medicea (siena), an underrated monument that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey. Next, head to Basilica Of San Domenico and admire its stunning features.

When you’re ready, continue to Siena Cathedral, a well-known church beloved by locals and tourists alike. Don't miss out on Piazza Del Campo, another highlight of the area that promises a memorable visit. Not far away, you’ll also find Pubblico Palace, a respected place to see that you won’t regret spending some extra time discovering.

At the end of the day, you will drive to Siena, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Siena. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Dine in style at Enoteca I Terzi, a top recommendation for dinner tonight. Or, for a change of pace, Ristorante Tar-Tufo boasts a menu that's sure to impress. Also, be sure to check out Antica Trattoria Papei. Known as a local hotspot, it’s a great choice for tonight in Siena.

Continue your lively evening at Meet Life Cafè, a perfect place for winding down or revving up the night, depending on which mood you’re in. Maudit Pub is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Bar Impero Siena ensures a night out tailored to your taste.

Celebrate another amazing day of your road trip adventure in Italy!

On day 8 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Rome are on today's agenda. In the evening, you’ll end up in Rome, where you will stay for 2 nights.

Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Rome.

Rome’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Siena behind. This drive usually takes around 2 hours 42 min. Rome welcomes you with a multitude of unique vacation experiences.

Set out on a self-guided sightseeing tour at Colosseum and explore the picture-perfect features. Next, make your way to Roman Forum, another highlight in Rome. When you’re done exploring the archeological site, continue to Spanish Steps, an enchanting public square.

Nearby, you will also find Piazza Di Spagna. This iconic public square is a top place to see in the area. Lastly, head to Trevi Fountain, a visually striking monument that is perfect for some final exploring in the city.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Savor the flavors at La Bottega Roma, a top pick for dinner tonight. Alternatively, Pasta In Corso beckons with its unique menu offerings. Also, consider Trattoria Vecchia Roma. With its consistent customer satisfaction, it’s an excellent option for dining in Rome tonight.

Continue the enjoyment post-dinner at La Botticella Of Poggi Giovanni, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Almalu Trastevere offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Bar Viminale Di Pepi Maurilio. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

On day 9 of your road trip, you’ll start and end your day in Rome, where you still have 1 night left. You'll spend part of the day exploring places of interest outside the immediate city, including Vatican City and Rome.

Set aside time today to explore Trastevere, a standout neighborhood that reflects the essence of the city. While you're there, you'll also be within reach of some of the city's top landmarks, making it easy to maximize your day.

Awaiting your discovery is the iconic Pantheon, an instagrammable monument in Rome. Next, go to Piazza Navona.

Upon reaching Vatican City, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Vatican Museums, a world-famous art museum that everyone visiting Vatican City should see. Next, head to Sistine Chapel.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at RomAntica, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Coso Ristorante, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of DEROMA - Farine Romane, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Let the evening flow smoothly from dinner to drinks at Sant' Eustachio Caffè, a top-rated bar in the area. For other recommendations, Yellowsquare Rome provides a perfect setting for rounding out your night with style and great drinks. Likewise, Caffè Portofino offers a memorable night with diverse drink options and excellent service.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Experience an unparalleled adventure on day 10 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Santa Maria degli Angeli and Valecchie. At the end of the day, you will retreat to the hotel of your choice in Santa Maria degli Angeli, where will spend 1 night.

Fasten your seatbelt and make your way to your next stop — Santa Maria degli Angeli, home to many well-known sights in the region. Keep in mind that your travel time from Rome to Santa Maria degli Angeli may take around 2 hours 22 min without traffic disruptions. Upon arrival in Santa Maria degli Angeli, we highly recommend checking out some of the top attractions.

One of our top recommendations for your sightseeing is Mount Subasio. Spend some time admiring the romantic features of the mountain range before you continue to your next stop. Then, head to Pinacoteca Comunale Palazzo Vallemani. This beloved art gallery is a traveler-favorite in the town.

If you're keen to see more, continue to Basilica Of San Francesco D'assisi. Feed your curiosity by learning something new about the church. Next, take your journey to Piazza Del Comune, an often recommended public square.

Savor the day by heading to Chiesa Di San Pietro, a beloved church that draws visitors from near and far.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Santa Maria degli Angeli. Santa Maria degli Angeli offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Santa Maria degli Angeli's most popular restaurants, and connect with friendly locals for a true cultural experience.

To truly maximize your evening out, consider visiting Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings after dinner. This bar is known for offering some of the best drinks and vibes in the city.

Savor another day of unforgettable experiences in Italy!

Your itinerary for day 11 of your road trip in Italy includes 1 stop and features some of the highlights of Bologna. At the end of the day, enjoy the comforts of a top-rated hotel in Trieste, where you'll spend 1 night.

After soaking in Santa Maria degli Angeli’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Bologna. Expect your car journey to take a minimum of 3 hours 9 min. When you arrive in Bologna, it's time to take a break from the road.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Fountain Of Neptune, Bologna, a curiosity-inducing monument that everyone visiting Bologna should see. Next, head to Piazza Maggiore. This romantic public square is one of the most top-rated attractions in the region.

If you're keen to see more, don’t miss out on Piazza Santo Stefano, an inviting public square popular among locals as well as travelers. Two Towers is an excellent attraction to visit next. Spend some time learning more about this captivating monument before you continue your journey. Lastly, visit San Martino, a culturally significant church and a top attraction in the city.

At the end of the day, you will drive to Trieste, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Trieste. Enjoy a relaxing evening as you savor delicious local cuisine.

Make sure to reserve a table at Caffè degli Specchi, an iconic dining spot in Trieste. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Osteria Istriano Of Giobi And Oxa, a popular restaurant in Trieste. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Chimera di Bacco, a hidden gem nestled in Trieste. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Keep the evening going at "life" New Bar Torinese Snc, a great choice for enjoying the after-dinner hours with a drink. You could also go to White Cafe, which offers a similarly pleasant setting and great drinks. Another option is Café James Joyce, which provides an inviting environment for unwinding after a busy day out.

Raise your glass to another unforgettable day in Italy!