10-Day Italy Self-Drive Road Trip With Itinerary from Pisa traveling east to Florence, Siena, Rome, and Orvieto

On day 2 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Florence. When you’re not sightseeing, take time to relax at your chosen hotel in Florence, where you’ll be staying for 2 nights.

Fasten your seatbelt and make your way to your next stop — Florence, home to many well-known sights in the region. Keep in mind that your travel time from Pisa to Florence may take around 1 hour 19 min without traffic disruptions. Upon arrival in Florence, we highly recommend checking out some of the top attractions.

Basilica Of Santa Croce In Florence is a notable church we recommend visiting today. Discover its culturally significant features before continuing your self-guided tour to Bargello National Museum, a photogenic museum that’s well-regarded in the area.

Next, stop by Palazzo Vecchio, a culturally significant palace. While you’re nearby, don’t forget to visit Uffizi Gallery, a romantic and truly unique art gallery. End your sightseeing at Ponte Vecchio, an iconic historical landmark that’s highly recommended by travelers passing through the city.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Florence, it's often a good idea to reserve a table in advance.

Dine in style at Ristorante Oliviero 1962, a top recommendation for dinner tonight. Or, for a change of pace, Di Poneta Novoli boasts a menu that's sure to impress. Also, be sure to check out Caffe San Firenze. Known as a local hotspot, it’s a great choice for tonight in Florence.

Extend your evening after a delightful meal by visiting Manifattura, which offers the perfect atmosphere for a night out. Moreover, Se·sto On Arno Rooftop Bar is another popular option for a drink or two. Likewise, Il Vinile also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Relax and look forward to more memorable moments to come!

On day 3 of your road trip in Italy, you’ll start and end your day in Florence, but spend the day exploring what’s beyond the city. Since you still have 1 night to spend in Florence, there’s no need to rush. Experience Florence and Greti to the fullest today with this curated day itinerary.

To truly experience Florence, make sure to drop by Central Market. This captivating food market is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Medici Chapels, one of the city’s best highlights.

Next, check out Cathedral Of Santa Maria Del Fiore, one of the most top-rated places to see in Florence. This church is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Galleria Dell'accademia. Wander around and soak in the respected atmosphere this art gallery offers. Then, head to David, a top-rated statue that adds another dimension to your day.

It’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Greti may take around 41 min. Upon your arrival in Greti, you’ll be greeted with the opportunity to do some sightseeing and exploring.

One of our top recommendations for your sightseeing is Villa Calcinaia - Conti Capponi. Spend some time admiring the visually striking features of the winery before you continue to your next stop.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Florence.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine.

Treat yourself to a delightful dinner at Ditta Artigianale, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Trattoria Da Burde? It's another excellent option with a diverse menu. Consider reserving a table at Casa Toscana as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Florence.

Unwind after your meal by stepping into Bar 50 Rosso. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Bitter Bar offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Archea Brewery, another top-rated bar in the area.

Head back to your accommodation in Florence and get some rest to prepare for another magical day of your road trip in Italy.

Experience an unparalleled adventure on day 4 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Siena. At the end of the day, you will retreat to the hotel of your choice in Siena, where will spend 1 night.

Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Siena.

Siena’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Florence behind. This drive usually takes around 1 hour 12 min. Siena welcomes you with a multitude of unique vacation experiences.

Set out on a self-guided sightseeing tour at Siena Cathedral and explore the history-steeped features. Next, make your way to Battistero Di San Giovanni Battista, another highlight in Siena. When you’re done exploring the church, continue to Pubblico Palace, a picture-perfect palace.

Nearby, you will also find Piazza Del Campo. This spectacular public square is a top place to see in the area. Lastly, head to Tower Of Mangia, a picture-perfect monument that is perfect for some final exploring in the city.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Siena. Siena offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Siena. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delicious dinner at Enoteca I Terzi, an excellent option for tonight's dining. Looking for something different? Ristorante Tar-Tufo offers a tantalizing alternative with its diverse menu. And don’t miss Antica Trattoria Papei. Known for great service, it’s a fantastic choice for tonight in Siena.

Explore the vibrant nightlife at Meet Life Cafè after your meal, a hub for lively evenings and memorable moments. Or, head to Maudit Pub for a great selection of flavorful drinks and a charming setting. Furthermore, Bar Impero Siena is perfect for those looking to extend their night with a touch of local flavor.

Raise your glass and celebrate another amazing day of your road trip in Italy!

On day 5 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Rome are on today's agenda. In the evening, you’ll end up in Rome, where you will stay for 3 nights.

When you’ve had your share of Siena, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Rome. Your travel time is around 2 hours 42 min.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Colosseum, an iconic archeological site that everyone visiting Rome should see. Next, head to Roman Forum. This UNESCO world heritage-designated archeological site is one of the most iconic attractions in the region.

If you're keen to see more, don’t miss out on Castel Sant'angelo, a culturally significant castle popular among locals as well as travelers. Trevi Fountain is an excellent attraction to visit next. Spend some time learning more about this globally renowned monument before you continue your journey. Lastly, visit Piazza Di Spagna, a visually striking public square and a top attraction in the city.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Enjoy a lovely meal at La Bottega Roma, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Pasta In Corso is another top choice with a popular menu. You could also check for a table at Trattoria Vecchia Roma. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Rome tonight.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, La Botticella Of Poggi Giovanni stands out as an excellent choice for a post-dinner cocktail. Alternatively, Almalu Trastevere offers an ideal atmosphere to enjoy the pleasures of the night. Bar Viminale Di Pepi Maurilio is also a great option that provides a perfect setting for a relaxing evening.

Say good night to Rome and look forward to another great day of your road trip in Italy!

On day 6 of your road trip, you'll get the chance to experience Vatican City and Rome. At the end of the day, you'll drive back to Rome, where you still have 2 nights left to stay.

At the top of the list of things to do today is to explore Trastevere, a neighborhood that captures the true essence of Vatican City. Take your time to uncover its best sides and enjoy its proximity to many of the area’s best attractions.

Check out the widely recognized public square, Campo De' Fiori. As you explore Rome’s charming streets, take in the lively atmosphere and get to know the character of the city.

Set your GPS to Vatican City, Vatican City and hit the road. Expect a journey of approximately 11 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Vatican City beckons with new experiences!

Time flies when you're having fun! But don't forget to stop for a bit to eat and drink between your adventures. When you're rested and recharged, head to Saint Peter's Square, a notable square that offers a unique experience. Be sure to also explore Vatican Museums, a nearby art museum, highly recommended by other travelers.

When you’re done exploring for the day, you’ll return to Rome and your accommodation.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for a true cultural experience.

Don’t miss out on dining at RomAntica, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Coso Ristorante, another top spot with a mouthwatering menu. You might also want to secure a reservation at DEROMA - Farine Romane. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Cap off your dinner by heading to Sant' Eustachio Caffè, ideal for a leisurely evening with a drink in hand. Yellowsquare Rome is another bar that offers an enjoyable setting. Similarly, Caffè Portofino is also a popular place to go on a night out, perfect for relaxing and socializing.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Wake up to day 7 of your road trip in Italy. On this day, you’ll embark on an exciting expedition discovering the enchanting sights and activities of Rome and Tivoli. With 1 night to stay in Rome, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

Piazza Navona leaves a lasting impression. This public square is one of the most iconic places to visit in Rome. Next, head to Pantheon, a world-famous monument, known for its photogenic features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Piazza Del Popolo. This history-steeped public square is a highly recommended experience. Nearby, you'll also find Villa Borghese Visit these for an interesting touch to your journey.

When you’ve had your share of Rome, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Tivoli. Your travel time is around 44 min.

For a more meaningful self-guided tour of the city's best attractions, visit Villa D'este, a captivating palace that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Hotel de Russie, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of La Taverna Italiana, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of The Parrot Bar, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Keep the evening going at The Apartment Bar Roma, a great choice for enjoying the after-dinner hours with a drink. You could also go to Hotel Hassler Roma, which offers a similarly pleasant setting and great drinks.

Celebrate another amazing day of your road trip adventure in Italy!

Your itinerary for day 8 of your road trip in Italy includes 1 stop and features some of the highlights of Orvieto. At the end of the day, enjoy the comforts of a top-rated hotel in Orvieto, where you'll spend 1 night.

When you’re ready to jump back into the car and say goodbye to Rome, you’ll hit the road in the direction of Orvieto. This drive usually takes around 1 hour 35 min.

For a more meaningful self-guided tour of the village's best attractions, visit Well Of St. Patrick, a locally renowned monument that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey.

Fasten your seatbelt and make your way to your next stop — Orvieto, home to many well-known sights in the region. Keep in mind that your travel time from Rome to Orvieto may take around 1 hour 35 min without traffic disruptions. Upon arrival in Orvieto, we highly recommend checking out some of the top attractions.

Spend your afternoon discovering Orvieto Cathedral, a locally renowned church known for its visually striking features. Next, continue your sightseeing at Museo Dell'opera Del Duomo, an underrated museum.

If you're starting to feel hungry, this is a great time for a break at a nearby restaurant or cafe. When you're ready for more, stop by Orvieto Underground and uncover the details of this photogenic cave system. Make sure to also explore Torre Del Moro Orvieto, an increasingly popular monument. For your last stop, consider Pozzo Della Cava, a photogenic cave that many travelers find worth the detour.

When you’re done exploring for the day, you’ll drive to your hotel in Orvieto. Check in and relax before you head out to tour the town.

Indulge in a memorable dining experience at one of Orvieto's most popular restaurants, and connect with friendly locals for a true cultural experience.

After your meal, keep the night alive at a bar like Bar Duomo, known for its lively atmosphere.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

Dive into day 9 of your remarkable road trip in Italy. Today you'll explore 1 destination, including San Gimignano. At the end of the day, you’ll unwind at one of the finest accommodations in Pisa, where you'll spend 1 night.

Set your GPS to San Gimignano and hit the road. Expect a journey of approximately 1 hour 59 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. San Gimignano beckons with new experiences!

Savor the day by heading to Porta San Giovanni, a frequently visited monument that draws visitors from near and far. When you're done, continue to Sangimignano1300, where you can soak in the respected surroundings.

Next, explore Palazzo Comunale, Pinacoteca, Torre Grossa, yet another often recommended place to see in the area. After the museum, make time to go to Piazza Del Duomo. This history-steeped public square is well worth the visit. Lastly, head to Parco Della Rocca, a locally appreciated park you won’t want to miss.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Pisa. Pisa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Pisa's best restaurants.

Make sure to reserve a table at Ristorante Capodimonte Pisa, an iconic dining spot in Pisa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of La Locanda Dei Pisani Doc Pisa, a popular restaurant in Pisa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Baribaldi Pisa, a hidden gem nestled in Pisa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

If you’re not ready to end the night just yet, Bar Mocambo offers a perfect venue to relax and savor a drink. Similarly, Tree is well-suited for those looking to unwind in a social setting. Chupiteria is another excellent spot to enjoy a nightcap after a delightful meal.

Relax and recharge in preparation for another adventurous day in Italy!