7-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Kalambaka, Ioannina, and Metsovo

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Photo of bird's eye view to the promenade of Thessaloniki.
Photo of Saint Paul cathedral in Thessaloniki, Greece.
7-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Kalambaka, Ioannina, and Metsovo
7-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Kalambaka, Ioannina, and Metsovo
7-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Kalambaka, Ioannina, and Metsovo
7-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Kalambaka, Ioannina, and Metsovo
7-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Kalambaka, Ioannina, and Metsovo
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Experience the freedom of the open road on an unforgettable 7-day road trip in Greece! Embark on a self-drive tour that caters to every traveler, featuring destinations like Thessaloniki, Kastraki, Kalambaka, Perama, Ioannina, Anilio, Metsovo, and Vergina.

This perfectly planned road trip itinerary takes you through some of the best places to see in Greece. You will spend 3 nights in Thessaloniki, 1 night in Kalambaka, 1 night in Ioannina, and 1 night in Metsovo. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Thessaloniki, Kastraki, Kalambaka, Perama, Ioannina, Anilio, Metsovo, and Vergina, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65
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Day1

Day 1

  • Thessaloniki - Arrival day
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  • Ladadika
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Welcome to Thessaloniki, the perfect starting point for your road trip in Greece! Pick up your rental car and let the adventure begin. You will spend 2 nights discovering what to see in Thessaloniki before embarking on the next leg of your journey.

Thessaloniki is a beautiful city with plenty to discover. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Thessaloniki. Check-in typically starts around 2 to 4 PM at hotels in Greece. We recommend staying at a central location for easy access to key areas in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Kitchen Bar, an iconic dining spot in Thessaloniki. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of The Greek, a popular restaurant in Thessaloniki. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Phanós, a hidden gem nestled in Thessaloniki. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Beetle Bar stands out as an excellent choice for a post-dinner cocktail. Alternatively, Vogatsikou 3 offers an ideal atmosphere to enjoy the pleasures of the night. Souel is also a great option that provides a perfect setting for a relaxing evening.

Raise a toast to the start of your 7-day road trip in Greece!

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Day2

Day 2

  • Thessaloniki
  • More

Drive 6 km, 59 min

  • The Umbrellas by Zongolopoulos
  • Museum of Byzantine Civilization
  • Archaeological Museum of Thessaloniki
  • White Tower of Thessaloniki
  • Aristotelous Square
  • Tsimiski Street
  • More

Day 2 of your road trip will take you to the best attractions Thessaloniki has to offer. Cherish the 1 night you have left in the city and use the provided itinerary to discover what to see in Thessaloniki.

Thessaloniki is brimming with adventures. Tsimiski Street is a street that stands out as one of the must-see places in Thessaloniki. Take a moment to explore its distinct atmosphere, and don’t miss the popular sightseeing spots just a short walk away.

Enjoy all that The Umbrellas Sculpture By Zogolopoulos has to offer. This is a well-known art installation you should not miss. Another must-see is Museum Of Byzantine Culture, a frequently visited museum in Thessaloniki.

When you’re ready for the next sight, head to Archaeological Museum Of Thessaloniki. From there, take a leisurely stroll to White Tower Of Thessaloniki, another of the city’s spectacular attractions. We recommend continuing your self-guided tour at Aristotelous Square, a history-steeped place of interest in the city.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Greece. You can explore and select activities under each day of your itinerary.

For an unforgettable shopping experience, visit Tsimiski Street, the top shopping destination in Thessaloniki. Browse local boutique shops and stores, each offering delightful surprises. Find unique souvenirs or items to take home. After shopping, explore what Tsimiski Street has to offer, including attractions, essential services, and vibrant community activities.

Thessaloniki is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Thessaloniki.

Treat yourself to a delightful dinner at Mamalouka, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Clochard? It's another excellent option with a diverse menu. Consider reserving a table at Sofi's House Restaurant as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Thessaloniki.

Extend your evening after a delightful meal by visiting Castra- All Day Terrace Bar, which offers the perfect atmosphere for a night out. Moreover, Barbaben - Bar/ba/ben is another popular option for a drink or two. Likewise, Apallou also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Say good night to Thessaloniki and look forward to another great day of your road trip in Greece!

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Day3

Day 3

  • Thessaloniki
  • Kastraki
  • Meteora
  • More

Drive 240 km, 3 hours 33 min

  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Monastery of Varlaam
  • Main Observation Deck of Meteora
  • Natural History Museum of Meteora and Mushroom Museum
  • Greek Education Museum
  • More

Your itinerary for day 3 of your road trip in Greece includes 2 stops and features some of the highlights of Kastraki and Kalambaka. At the end of the day, enjoy the comforts of a top-rated hotel in Kalambaka, where you'll spend 1 night.

After soaking in Thessaloniki’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Kastraki. Expect your car journey to take a minimum of 2 hours 53 min. When you arrive in Kastraki, it's time to take a break from the road.

Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour is an up-and-coming monastery we recommend visiting today. Discover its stunning features before continuing your self-guided tour to Monastery Of Varlaam, a stunning monastery that’s well-regarded in the area.

Next, stop by Main Observation Deck Of Meteora, a romantic observation deck.

Fasten your seatbelt and make your way to your next stop — Kalambaka, home to many well-known sights in the region. Keep in mind that your travel time from Kastraki to Kalambaka may take around 11 min without traffic disruptions. Upon arrival in Kalambaka, we highly recommend checking out some of the top attractions.

Natural History Museum Of Meteora And Mushroom Museum is an often recommended museum we recommend visiting today. Discover its visually striking features before continuing your self-guided tour to Greek Education Museum, a standout museum that’s well-regarded in the area.

At the end of the day, you will drive to Kalambaka, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Kalambaka. Enjoy a relaxing evening as you savor delicious local cuisine.

Relax and recharge in preparation for another adventurous day in Greece!

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Day4

Day 4

  • Meteora
  • Perama
  • Ioannina
  • More

Drive 107 km, 2 hours 26 min

  • Cave of Perama
  • Silversmithing Museum
  • Ich Kale Acropolis of Ioannina
  • Ioannina Castle
  • Litharitsia park
  • The Clock Tower of Ioannina
  • More

On day 4 of your exciting self-drive vacation in Greece, you’ll soak in the magnificence of 2 destinations, including Perama and Ioannina. When you’re not sightseeing, take time to relax at your chosen hotel in Ioannina, where you’ll be staying for 1 night.

Continue your road trip and head to your next destination, Perama. This car ride takes around 1 hour 42 min.

One of our top recommendations for your sightseeing is Cave Of Perama. Spend some time admiring the visually striking features of the cave before you continue to your next stop.

Ioannina’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Perama behind. This drive usually takes around 12 min. Ioannina welcomes you with a multitude of unique vacation experiences.

For a more meaningful self-guided tour of the town's best attractions, visit Silversmithing Museum Of Ioannina, an increasingly popular museum that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey. Next, head to Ic Kale Acropolis Of Ioannina and admire its breathtaking features.

When you’re ready, continue to Ioannina Castle, a popular castle beloved by locals and tourists alike. Don't miss out on Litharitsia Park, another highlight of the area that promises a memorable visit. Not far away, you’ll also find The Clock Tower Of Ioannina, a standout place to see that you won’t regret spending some extra time discovering.

When you’re done exploring for the day, you’ll drive to your hotel in Ioannina. Check in and relax before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Ioannina. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a lovely dining experience at To Dodeka Cafe Bar, a popular restaurant in Ioannina. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Ioannina at Mustagogia, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Accademia Del Panino. It’s yet another ideal choice to enhance your time in Ioannina tonight.

Continue the enjoyment post-dinner at ⚜ V E D E M A ⚜, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Hogwarts Tales And Spirits offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Chevalier. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Raise your glass and celebrate another amazing day of your road trip in Greece!

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Day5

Day 5

  • Ioannina
  • Anilio
  • Metsovo
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Drive 56 km, 1 hour 15 min

  • Καταρράκτης Ανήλιου
  • Αβερώφειος Κήπος
  • Metsovo Folk Art Museum (Tossizza Mansion)
  • Metsovo square
  • Averoff Art Gallery
  • More

On day 5 of your road trip in Greece, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Anilio and Metsovo are on today's agenda. In the evening, you’ll end up in Metsovo, where you will stay for 1 night.

Throughout the day, make sure to take breaks to appreciate the surroundings.

When you’ve had your share of Ioannina, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Anilio. Your travel time is around 44 min.

Savor the day by heading to Katarraktis Anilioy, a curiosity-inducing waterfall that draws visitors from near and far.

Continue your road trip and head to your next destination, Metsovo. This car ride takes around 11 min.

When you're ready for some sights, head to Averofeios Kipos, a worthwhile park in Metsovo. Explore its instagrammable features at your own pace before you continue your journey to your next attraction, Metsovo Folk Art Museum (tossizza Mansion). This underrated museum is a top recommendation in the area.

When you’re ready to explore more, Metsovo Square is an excellent choice. Spend some time discovering what some claim to be the most enchanting public square in the region. Next, continue your sightseeing at the up-and-coming Averoff Art Gallery and discover what makes this art gallery unique.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Metsovo. Metsovo offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Metsovo's best restaurants.

Enjoy a lovely meal at Ta 5 FFFFF, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Cafe Petrino is another top choice with a popular menu. You could also check for a table at Fame Metsovo. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Metsovo tonight.

Unwind after your meal by stepping into Karma. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Krini Cafe Metsovo offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Stul Cafe, another top-rated bar in the area.

Relax and look forward to more memorable moments to come!

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Day6

Day 6

  • Metsovo
  • Vergina
  • Thessaloniki
  • More

Drive 236 km, 2 hours 41 min

  • Polycentric Museum of Aigai (Aegae) - Main Building
  • Museum of the Royal Tombs at Aigai (Aegae)
  • More

Experience an unparalleled adventure on day 6 of your road trip in Greece. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Vergina. At the end of the day, you will retreat to the hotel of your choice in Thessaloniki, where will spend 1 night.

Fasten your seatbelt and make your way to your next stop — Vergina, home to many well-known sights in the region. Keep in mind that your travel time from Metsovo to Vergina may take around 1 hour 42 min without traffic disruptions. Upon arrival in Vergina, we highly recommend checking out some of the top attractions.

Spend your afternoon discovering Polycentric Museum Of Aigai (aegae) - Main Building, a locally appreciated museum known for its photogenic features. Next, continue your sightseeing at Museum Of The Royal Tombs At Aigai (aegae), an often recommended museum.

At the end of the day, you will drive to Thessaloniki, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Thessaloniki's most popular restaurants, and connect with friendly locals for a true cultural experience.

Have a fantastic dining experience at Enoches Bar, a highly recommended choice for tonight's dinner. If you're looking to mix things up, O Loytros offers an enticing alternative with its varied menu. Additionally, rOOTS is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Thessaloniki.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Peiratis Cafe-bar, a well-loved spot among locals and tourists. Or, head to In Rock Cafe Bar. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Tribeca, another top-rated place in the area.

As the sun sets, rest up and recharge for the next leg of your road trip in Greece.

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Day7

Day 7

  • Thessaloniki - Departure day
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  • Arch of Galerius
  • More

Day 7 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Arch Of Galerius And Rotunda. This well-known monument is a hotspot among locals.

For a last-minute shopping spree in Thessaloniki, Tsimiski Street is nearby. Enjoy a variety of retail stores, dining options, and essential services in one convenient location. Browse through boutiques to find unique and stylish fashion pieces to take home.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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