5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling south to Trikala and Larissa

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Photo of bird's eye view to the promenade of Thessaloniki.
Photo of Saint Paul cathedral in Thessaloniki, Greece.
5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling south to Trikala and Larissa
5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling south to Trikala and Larissa
5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling south to Trikala and Larissa
5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling south to Trikala and Larissa
5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling south to Trikala and Larissa
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Explore the best of Greece on a remarkable 5-day road trip! Combine exploration with relaxation on a self-drive tour featuring Thessaloniki, Trikala, Kastraki, Larissa, Katerini, Vergina, and Kastanéa.

This perfectly planned road trip itinerary takes you through some of the best places to see in Greece. You will spend 2 nights in Thessaloniki, 1 night in Trikala, and 1 night in Larissa. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Thessaloniki, Trikala, Kastraki, Larissa, Katerini, Vergina, and Kastanéa, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65
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Day1

Day 1

  • Thessaloniki - Arrival day
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  • Ladadika
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Your road trip adventure in Greece begins as soon as you reach Thessaloniki and pick up your car. You’ll stay here for 1 night and explore what to see in Thessaloniki, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Thessaloniki is a beautiful city with plenty to discover. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Thessaloniki. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Greece. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Enjoy a lovely dining experience at Kitchen Bar, a popular restaurant in Thessaloniki. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Thessaloniki at The Greek, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Phanós. It’s yet another ideal choice to enhance your time in Thessaloniki tonight.

Extend your evening after a delightful meal by visiting Beetle Bar, which offers the perfect atmosphere for a night out. Moreover, Vogatsikou 3 is another popular option for a drink or two. Likewise, Souel also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Raise a toast to the start of your 5-day road trip in Greece!

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Day2

Day 2

  • Thessaloniki
  • Trikala
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Drive 217 km, 3 hours 15 min

  • Aristotelous Square
  • Agias Sofias Square
  • Arch of Galerius
  • White Tower of Thessaloniki
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On day 2 of your road trip in Greece, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Thessaloniki are on today's agenda. In the evening, you’ll end up in Trikala, where you will stay for 1 night.

Awaiting your discovery is the notable Aristotelous Square, a history-steeped public square in Thessaloniki. Next, go to Agias Sofias Square.

After visiting Aristotelous Square and Agias Sofias Square, have a stroll along Thessaloniki's streets and take in the local charm. Continue your sightseeing by heading to Arch Of Galerius And Rotunda. This eye-catching monument offers a unique experience. White Tower Of Thessaloniki is another noteworthy attraction worthwhile a visit.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Trikala. Trikala offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Trikala, it's often a good idea to reserve a table in advance.

Don’t miss out on dining at ALVEO, a top-rated dining destination in Trikala. If you're in the mood to try something new, consider Trikala Fortress, another top spot with a mouthwatering menu. You might also want to secure a reservation at Palia Istoria. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Trikala this evening.

Round off your dining experience by visiting Soyita Art Cafe, a prime location for a drink. Alternatively, explore the distinctive characteristics of Factory Café, a bar catering to every mood and preference. The Love Shake likewise offers a unique atmosphere, perfect for a memorable night out.

Raise your glass to another unforgettable day in Greece!

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Day3

Day 3

  • Trikala
  • Kastraki
  • Larissa
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Drive 118 km, 2 hours 53 min

  • Matsopoulos Park
  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Monastery of Varlaam
  • Meteora
  • More

Dive into day 3 of your remarkable road trip in Greece. Today you'll explore 2 destinations, including Trikala and Kastraki. At the end of the day, you’ll unwind at one of the finest accommodations in Larissa, where you'll spend 1 night.

No visit to Trikala is complete without Matsopoulos Park. This beloved park is one of the top attractions in the city.

Embrace the thrill of the open road as you wave goodbye to Trikala and set your GPS to Kastraki. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 37 min. Upon reaching Kastraki, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour is a worthwhile monastery we recommend visiting today. Discover its UNESCO world heritage-listed features before continuing your self-guided tour to Monastery Of Varlaam, a picture-perfect monastery that’s well-regarded in the area.

Next, stop by Meteora, an inviting monastery.

When you’re done exploring for the day, you’ll drive to your hotel in Larissa. Check in and relax before you head out to tour the city.

Indulge in a memorable dining experience at one of Larissa's most popular restaurants, and connect with friendly locals for a true cultural experience.

Enjoy a delicious meal at Nonna Rossa, a top-rated dining destination in Larissa. If you're in the mood to try something new, consider Vosporos | Restaurant • Bar, another top spot with a mouthwatering menu. You might also want to secure a reservation at THE ALLEY. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Larissa this evening.

Extend your evening after a delightful meal by visiting Sherlock Easy Bar, which offers the perfect atmosphere for a night out. Moreover, Kiou is another popular option for a drink or two. Likewise, Wisedog also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Take some time to reflect on your day and savor another beautiful night in Greece.

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Day4

Day 4

  • Larissa
  • Katerini
  • Vergina
  • Kastanéa
  • Thessaloniki
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Drive 259 km, 4 hours 15 min

  • Katerini Municipal Park
  • Museum of the Royal Tombs at Aigai (Aegae)
  • Holy Monastery of the Virgin Mary Soumela
  • More

Experience an unparalleled adventure on day 4 of your road trip in Greece. This exciting part of your journey invites you to discover the renowned landmarks in 3 places, which are Katerini, Vergina, and Kastanéa. At the end of the day, you will retreat to the hotel of your choice in Thessaloniki, where will spend 1 night.

Set your GPS to Katerini and hit the road. Expect a journey of approximately 1 hour 5 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Katerini beckons with new experiences!

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Katerini Municipal Park, a worthwhile park that everyone visiting Katerini should see.

After soaking in Katerini’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Vergina. Expect your car journey to take a minimum of 53 min. When you arrive in Vergina, it's time to take a break from the road.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Museum Of The Royal Tombs At Aigai (aegae), an intriguing museum that everyone visiting Vergina should see.

It’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Kastanéa may take around 40 min. Upon your arrival in Kastanéa, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Holy Shrine Of The Virgin Mary Soumela, a worthwhile church that everyone visiting Kastanéa should see.

At the end of the day, you will drive to Thessaloniki, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Thessaloniki. Enjoy a relaxing evening as you savor delicious local cuisine.

Treat yourself to a delicious dinner at Mamalouka, an excellent option for tonight's dining. Looking for something different? Clochard offers a tantalizing alternative with its diverse menu. And don’t miss Sofi's House Restaurant. Known for great service, it’s a fantastic choice for tonight in Thessaloniki.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Castra- All Day Terrace Bar, a well-loved spot among locals and tourists. Or, head to Barbaben - Bar/ba/ben. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Apallou, another top-rated place in the area.

As the sun sets, rest up and recharge for the next leg of your road trip in Greece.

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Day5

Day 5

  • Thessaloniki - Departure day
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  • The Umbrellas by Zongolopoulos
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Day 5 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting The Umbrellas Sculpture By Zogolopoulos, an enchanting art installation before you head out.

Take some time to indulge in shopping at Thessaloniki’s popular marketplace, Modiano Market. Look for keepsakes or souvenirs to remind you of your trip.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

If you're in the mood for something new, try O Loytros, another premier location with a delectable menu.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
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Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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