5-Day the Czech Republic Self-Drive Road Trip With Itinerary from Brno traveling west to Prague

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Photo of amazing view of the old town and Cathedral of St. Peter and Paul in Brno, Czech Republic.
Photo of building in Denis Gardens in the center of Brno city, Czech Republic.
5-Day the Czech Republic Self-Drive Road Trip With Itinerary from Brno traveling west to Prague
5-Day the Czech Republic Self-Drive Road Trip With Itinerary from Brno traveling west to Prague
5-Day the Czech Republic Self-Drive Road Trip With Itinerary from Brno traveling west to Prague
5-Day the Czech Republic Self-Drive Road Trip With Itinerary from Brno traveling west to Prague
5-Day the Czech Republic Self-Drive Road Trip With Itinerary from Brno traveling west to Prague
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Explore the best of the Czech Republic on a remarkable 5-day road trip! Combine exploration with relaxation on a self-drive tour featuring Brno, Prague, Karlštejn, and Telč.

This perfectly planned road trip itinerary takes you through some of the best places to see in the Czech Republic. You will spend 2 nights in Brno and 2 nights in Prague. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in the Czech Republic. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Brno, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover the Czech Republic on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in the Czech Republic. Prague Castle and Charles Bridge are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Brno, Prague, Karlštejn, and Telč, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of the Czech Republic. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in the Czech Republic.

Throughout your road trip in the Czech Republic, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in the Czech Republic.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in the Czech Republic fill up quickly, so book your spot early. Select a date and start planning your road trip in the Czech Republic today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
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Day1

Day 1

  • Brno - Arrival day
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  • Špilberk Castle
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Say hello to Brno! Your exciting road trip through the Czech Republic is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Brno for 1 night before you continue your adventure!

Brno is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Špilberk Castle. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Brno. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Brno, it's often a good idea to reserve a table in advance.

Dine in style at U Štíra, a top recommendation for dinner tonight. Or, for a change of pace, Bistro Franz boasts a menu that's sure to impress. Also, be sure to check out Noem Arch Restaurant. Known as a local hotspot, it’s a great choice for tonight in Brno.

Continue your lively evening at Bar Naproti, a perfect place for winding down or revving up the night, depending on which mood you’re in. Super Panda Circus is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Výčep Na Stojáka ensures a night out tailored to your taste.

Raise a toast to the start of your 5-day road trip in the Czech Republic!

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Day2

Day 2

  • Brno
  • Prague
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Drive 212 km, 2 hours 33 min

  • Vyšehrad
  • Charles Bridge
  • Prague Astronomical Clock
  • Old Town Square
  • More

On day 2 of your road trip in the Czech Republic, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Prague are on today's agenda. In the evening, you’ll end up in Prague, where you will stay for 2 nights.

As you explore Prague’s charming streets, take in the lively atmosphere and get to know the character of the city.

When you’re ready to jump back into the car and say goodbye to Brno, you’ll hit the road in the direction of Prague. This drive usually takes around 2 hours 4 min.

Spend your afternoon discovering Vyšehrad, a notable castle known for its history-steeped features. Next, continue your sightseeing at Charles Bridge, a world-famous historical landmark.

If you're starting to feel hungry, this is a great time for a break at a nearby restaurant or cafe. When you're ready for more, stop by Prague Astronomical Clock and uncover the details of this history-steeped historical landmark. Make sure to also explore Old Town Square, a timeless public square.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Prague. Prague offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Prague is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Prague.

Treat yourself to a delicious dinner at U Tellerů, an excellent option for tonight's dining. Looking for something different? Restaurace U Bansethů offers a tantalizing alternative with its diverse menu. And don’t miss Eska Restaurant and Bakery. Known for great service, it’s a fantastic choice for tonight in Prague.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Anonymous Shrink's Office stands out as an excellent choice for a post-dinner cocktail. Alternatively, Bar No. 7 - Prague offers an ideal atmosphere to enjoy the pleasures of the night. Kontakt Bar is also a great option that provides a perfect setting for a relaxing evening.

As the sun sets, rest up and recharge for the next leg of your road trip in the Czech Republic.

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Day3

Day 3

  • Prague
  • Karlštejn
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Drive 76 km, 1 hour 57 min

  • Karlštejn Castle
  • St. Vitus Cathedral
  • Prague Castle
  • Dancing House
  • Powder Tower
  • Malá Strana
  • More

On day 3 of your road trip, you’ll start and end your day in Prague, where you have 1 night left to stay.

Karlštejn is brimming with adventures. Malá Strana is a neighborhood that stands out as one of the must-see places in Karlštejn. Take a moment to explore its distinct atmosphere, and don’t miss the popular sightseeing spots just a short walk away.

No visit to Prague is complete without St. Vitus Cathedral. This spectacular church is one of the top attractions in the village. Proceed to Prague Castle, another must-visit attraction.

As you wander through the inviting streets of Prague, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Dancing House. This astonishing art installation is a traveler-favorite. Not far away, you’ll find Powder Tower, another key site on your sightseeing itinerary.

Set your GPS to Karlštejn and hit the road. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Karlštejn beckons with new experiences!

One of our top recommendations for your sightseeing is Karlštejn Castle. Spend some time admiring the history-steeped features of the castle before you continue to your next stop.

When you’re done exploring for the day, you’ll return to Prague and your accommodation.

Indulge in a memorable dining experience at one of Prague's most popular restaurants, and connect with friendly locals for a true cultural experience.

Have a fantastic dining experience at Brasileiro Restaurant, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Restaurant Meat Beer offers an enticing alternative with its varied menu. Additionally, Restaurace Století is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Prague.

After enjoying a fulfilling meal, continue your evening at Bowla Bar, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, The Saints offers a welcoming atmosphere for easing into the nightlife. Similarly, Beergeek Bar provides an excellent environment for a relaxed and enjoyable evening.

Get a good night's sleep and look forward to another great day on the road in the Czech Republic!

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Day4

Day 4

  • Prague
  • Telč
  • Brno
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Drive 285 km, 3 hours 55 min

  • Zámecká Zahrada
  • Telč château
  • Zacharias of Hradec Square
  • Telč House
  • Rozhledna Oslednice
  • More

Experience an unparalleled adventure on day 4 of your road trip in the Czech Republic. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Telč. At the end of the day, you will retreat to the hotel of your choice in Brno, where will spend 1 night.

Embrace the thrill of the open road as you wave goodbye to Prague and set your GPS to Telč. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 1 hour 54 min. Upon reaching Telč, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

When you're ready for some sights, head to Castle Garden, an underrated castle in Telč. Explore its visually striking features at your own pace before you continue your journey to your next attraction, Telč Château. This locally appreciated castle is a top recommendation in the area.

When you’re ready to explore more, Zacharias Of Hradec Square is an excellent choice. Spend some time discovering what some claim to be the most romantic public square in the region. Next, continue your sightseeing at the intriguing Telč and discover what makes this museum unique. If you’re up for one more stop in the town, head to Observation Tower Oslednice, a visually striking observation deck many travelers find the visit worthwhile.

At the end of the day, you will drive to Brno, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Brno. Enjoy a relaxing evening as you savor delicious local cuisine.

Enjoy a delicious meal at Nok Nok Restaurace Brno, a top-rated dining destination in Brno. If you're in the mood to try something new, consider Sportovní areál Komec, another top spot with a mouthwatering menu. You might also want to secure a reservation at Restaurace L'Eau Vive. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Brno this evening.

Explore the vibrant nightlife at Jazzový Bar U Kouřícího Králíka after your meal, a hub for lively evenings and memorable moments. Or, head to Queen Luxury Hookah Club for a great selection of flavorful drinks and a charming setting. Furthermore, Shot Bar is perfect for those looking to extend their night with a touch of local flavor.

Raise your glass to another unforgettable day in the Czech Republic!

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Day5

Day 5

  • Brno - Departure day
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  • Masarykova Street
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Day 5 of your road trip in the Czech Republic is your departure day. This is your chance to catch a last glimpse of Brno before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

One of the best things to do on your last day is to explore Masarykova Street, a street that you shouldn't miss while in Brno. Take your time to uncover its best sides and enjoy its proximity to many of the area’s best attractions.

For a shopping spree in Brno, we recommend the lively Galerie Vaňkovka. Here, you'll find a range of shops you can browse for some souvenir shopping.

Before you conclude your road trip in the Czech Republic, drop by another restaurant for a last chance at a memorable dining experience in Brno.

Treat yourself to a delightful dinner at HOTEL INTERNATIONAL BRNO, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Valoria? It's another excellent option with a diverse menu.

You’ll then say farewell to Brno. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in the Czech Republic!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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